Sexual health and serotonin 4 receptor brain binding in unmedicated patients with depression-a NeuroPharm study.

ABSTRACT: Sexual dysfunction is prominent in Major Depressive Disorder (MDD) and affects women with depression more than men. Patients with MDD relative to healthy controls have lower brain levels of the serotonin 4 receptor (5-HT₄R), which is expressed with high density in the striatum, i.e. a key hub of the reward system. Reduced sexual desire is putatively related to disturbed reward processing and may index anhedonia in MDD. Here, we aim to illuminate plausible underlying neurobiology of sexual dysfunction in unmedicated patients with MDD. We map associations between 5-HT₄R binding, as imaged with [¹¹C]SB207145 PET, in the striatum, and self-reported sexual function. We also evaluate if pre-treatment sexual desire score predicts 8-week treatment outcome in women.

SUBMITTER: Rasmussen AL 

PROVIDER: S-EPMC10325956 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature