Effector T cell chemokine IP-10 predicts cardiac recovery and clinical outcomes post-myocardial infarction.

ABSTRACT:

Background and aims

Preclinical data suggest that activation of the adaptive immune system is critical for myocardial repair processes in acute myocardial infarction. The aim of the present study was to determine the clinical value of baseline effector T cell chemokine IP-10 blood levels in the acute phase of ST-segment elevation myocardial infarction (STEMI) for the prediction of the left ventricular function changes and cardiovascular outcomes after STEMI.

Methods

Serum IP-10 levels were retrospectively quantified in two independent cohorts of STEMI patients undergoing primary percutaneous coronary intervention.

Results

We report a biphasic response of the effector T cell trafficking chemokine IP-10 characterized by an initial increase of its serum levels in the acu

SUBMITTER: Sopova K 

PROVIDER: S-EPMC10326041 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature