Monoclonal antibodies against lipopolysaccharide protect against <i>Pseudomonas aeruginosa</i> challenge in mice.

ABSTRACT: Pseudomonas aeruginosa is a common cause of hospital-acquired infections, including central line-associated bloodstream infections and ventilator-associated pneumonia. Unfortunately, effective control of these infections can be difficult, in part due to the prevalence of multi-drug resistant strains of P. aeruginosa. There remains a need for novel therapeutic interventions against P. aeruginosa, and the use of monoclonal antibodies (mAb) is a promising alternative strategy to current standard of care treatments such as antibiotics. To develop mAbs against P. aeruginosa, we utilized ammonium metavanadate, which induces cell envelope stress responses and upregulates polysaccharide expression. Mice were immunized with P. aeruginosa grown with ammonium metava

SUBMITTER: Kang J 

PROVIDER: S-EPMC10326049 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature