Ontology highlight
ABSTRACT:
SUBMITTER: Fang J
PROVIDER: S-EPMC10326052 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Fang Jie J Singh Shivendra S Cheng Changde C Natarajan Sivaraman S Sheppard Heather H Abu-Zaid Ahmed A Durbin Adam D AD Lee Ha Won HW Wu Qiong Q Steele Jacob J Connelly Jon P JP Jin Hongjian H Chen Wenan W Fan Yiping Y Pruett-Miller Shondra M SM Rehg Jerold E JE Koo Selene C SC Santiago Teresa T Emmons Joseph J Cairo Stefano S Wang Ruoning R Glazer Evan S ES Murphy Andrew J AJ Chen Taosheng T Davidoff Andrew M AM Armengol Carolina C Easton John J Chen Xiang X Yang Jun J
Nature communications 20230706 1
A lack of relevant genetic models and cell lines hampers our understanding of hepatoblastoma pathogenesis and the development of new therapies for this neoplasm. Here, we report an improved MYC-driven hepatoblastoma-like murine model that recapitulates the pathological features of embryonal type of hepatoblastoma, with transcriptomics resembling the high-risk gene signatures of the human disease. Single-cell RNA-sequencing and spatial transcriptomics identify distinct subpopulations of hepatobla ...[more]