Atypical primary central nervous system lymphoma and glioblastoma: multiparametric differentiation based on non-enhancing volume, apparent diffusion coefficient, and arterial spin labeling.

ABSTRACT:

Objectives

To evaluate the multiparametric diagnostic performance with non-enhancing tumor volume, apparent diffusion coefficient (ADC), and arterial spin labeling (ASL) to differentiate between atypical primary central nervous system lymphoma (PCNSL) and glioblastoma (GBM).

Methods

One hundred and fifty-eight patients with pathologically confirmed typical PCNSL (n = 59), atypical PCNSL (hemorrhage, necrosis, or heterogeneous contrast enhancement, n = 29), and GBM (n = 70) were selected. Relative minimum ADC (rADC_min), mean (rADC_mean), maximum (rADC_max), and rADC_max-min (rADC_dif) were obtained by standardization of the contralateral white matter. Maximum cerebral blood flow (CBF_max) was obtained according to t

SUBMITTER: Yu X 

PROVIDER: S-EPMC10326108 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature