Diagnostic and Therapeutic Updates in Leptomeningeal Disease.

ABSTRACT:

Purpose of review

Leptomeningeal disease (LMD) is a devastating complication of advanced metastatic cancer associated with a poor prognosis and limited treatment options. This study reviews the current understanding of the clinical presentation, pathogenesis, diagnosis, and treatment of LMD. We highlight opportunities for advances in this disease.

Recent findings

In recent years, the use of soluble CSF biomarkers has expanded, suggesting improved sensitivity over traditional cytology, identification of targetable mutations, and potential utility for monitoring disease burden. Recent studies of targeted small molecules and intrathecal based therapies have demonstrated an increase in overall and progression-free survival. In addition, there are several ongoing trials evaluatin

SUBMITTER: Roy-O'Reilly MA 

PROVIDER: S-EPMC10326117 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature