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New halimane and clerodane diterpenoids from Croton cnidophyllus.

ABSTRACT: Three new halimane furanoditerpenoids (1-3) and three new clerodane furanoditerpenoids (4-6), along with seven known terpenoids including four pimarane diterpenoids (7-10) and three norisoprenoids (11-13) were isolated from the 95% EtOH extracts of the plants of Croton cnidophyllus. The 2D structures including absolute configuration of new furanoditerpenoids (1-6) were elucidated by analysis of their HRMS and NMR data as well as comparison of experimental and calculated ECD curves. Bioassay revealed that two compounds (8 and 9) possessed certain inhibitory effects against NO production stimulated by LPS, with IC₅₀ values of 19.00 ± 1.76 and 21.61 ± 1.11 μM, respectively.

SUBMITTER: Wei X

PROVIDER: S-EPMC10326188 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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New halimane and clerodane diterpenoids from Croton cnidophyllus.

Wei Xun X Huang Jia-Luo JL Gao Hua-Hua HH Yuan Fang-Yu FY Tang Gui-Hua GH Yin Sheng S

Natural products and bioprospecting 20230706 1

Three new halimane furanoditerpenoids (1-3) and three new clerodane furanoditerpenoids (4-6), along with seven known terpenoids including four pimarane diterpenoids (7-10) and three norisoprenoids (11-13) were isolated from the 95% EtOH extracts of the plants of Croton cnidophyllus. The 2D structures including absolute configuration of new furanoditerpenoids (1-6) were elucidated by analysis of their HRMS and NMR data as well as comparison of experimental and calculated ECD curves. Bioassay reve ...[more]

PMID: 37410272

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