Insights into Leishmania donovani potassium channel family and their biological functions.

ABSTRACT: Leishmania donovani is the causative organism for visceral leishmaniasis. Although this parasite was discovered over a century ago, nothing is known about role of potassium channels in L. donovani. Potassium channels are known for their crucial roles in cellular functions in other organisms. Recently the presence of a calcium-activated potassium channel in L. donovani was reported which prompted us to look for other proteins which could be potassium channels and to investigate their possible physiological roles. Twenty sequences were identified in L. donovani genome and subjected to estimation of physio-chemical properties, motif analysis, localization prediction and transmembrane domain analysis. Structural predictions were also done. The channels were majorly

SUBMITTER: Paul A 

PROVIDER: S-EPMC10326225 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature