Expression and biological function of the cellular communication network factor 5 (CCN5) in primary liver cells.

ABSTRACT: The cellular (centralized) communication network (CCN) factor protein family contains six small secreted cysteine-rich proteins sharing high structural similarity. These matricellular proteins have vital biological functions in cell adhesion, migration, cell cycle progression, and control of production and degradation of extracellular matrix. However, in liver the biological functions of CCN proteins become most visible during hepatic injury, disease, and remodeling. In particular, most of the hepatic functions of CCN proteins were derived from CCN2/CTGF, which becomes highly expressed in damaged hepatocytes and acts as a profibrogenic molecule. On the contrary, CCN1/CYR61 seems to have opposite effects, while the biological activity during hepatic fibrosis is somewhat controversially disc

SUBMITTER: Borkham-Kamphorst E 

PROVIDER: S-EPMC10326238 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature