Anti-dense fine speckled 70 (DFS70) autoantibodies: correlates and increasing prevalence in the United States.

ABSTRACT:

Objective

Recent studies report high-titer anti-dense fine speckled 70 (DFS70) autoantibodies in persons with inflammatory conditions, but the clinical significance remains unclear. Our goals were to estimate anti-DFS70 autoantibody prevalence, identify correlates, and assess time trends.

Methods

Serum antinuclear antibodies (ANA) were measured by indirect immunofluorescence assay on HEp-2 cells in 13,519 participants ≥12 years old from three time periods (1988-1991, 1999-2004, 2011-2012) of the National Health and Nutrition Examination Survey. ANA-positive participants with dense fine speckled staining were evaluated for anti-DFS70 antibodies by enzyme-linked immunosorbent assay. We used logistic models adjusted for survey-design variables to estimate period-specific anti-D

SUBMITTER: Dinse GE 

PROVIDER: S-EPMC10326272 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature