The effects of enhancing angiotensin converting enzyme in myelomonocytes on ameliorating Alzheimer's-related disease and preserving cognition.

ABSTRACT: This review examines the role of angiotensin-converting enzyme (ACE) in the context of Alzheimer's disease (AD) and its potential therapeutic value. ACE is known to degrade the neurotoxic 42-residue long alloform of amyloid β-protein (Aβ₄₂), a peptide strongly associated with AD. Previous studies in mice, demonstrated that targeted overexpression of ACE in CD115⁺ myelomonocytic cells (ACE10 models) improved their immune responses to effectively reduce viral and bacterial infection, tumor growth, and atherosclerotic plaque. We further demonstrated that introducing ACE10 myelomonocytes (microglia and peripheral monocytes) into the double transgenic APP_SWE/PS1_ΔE9 murine model of AD (AD⁺ mice), diminished neuropathology and enhanced the co

SUBMITTER: Danziger R 

PROVIDER: S-EPMC10326285 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature