Determination of lethal electric field threshold for pulsed field ablation in ex vivo perfused porcine and human hearts.

ABSTRACT:

Introduction

Pulsed field ablation is an emerging modality for catheter-based cardiac ablation. The main mechanism of action is irreversible electroporation (IRE), a threshold-based phenomenon in which cells die after exposure to intense pulsed electric fields. Lethal electric field threshold for IRE is a tissue property that determines treatment feasibility and enables the development of new devices and therapeutic applications, but it is greatly dependent on the number of pulses and their duration.

Methods

In the study, lesions were generated by applying IRE in porcine and human left ventricles using a pair of parallel needle electrodes at different voltages (500-1500 V) and two different pulse waveforms: a proprietary biphasic waveform (Medtronic) and monophasic 48 × 100

SUBMITTER: Kos B 

PROVIDER: S-EPMC10326317 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature