Characterizing control of memory CD8 T cell differentiation by BTB-ZF transcription factor Zbtb20.

ABSTRACT: Members of the BTB-ZF transcription factor family regulate the immune system. Our laboratory identified that family member Zbtb20 contributes to the differentiation, recall responses, and metabolism of CD8 T cells. Here, we report a characterization of the transcriptional and epigenetic signatures controlled by Zbtb20 at single-cell resolution during the effector and memory phases of the CD8 T cell response. Without Zbtb20, transcriptional programs associated with memory CD8 T cell formation were up-regulated throughout the CD8 T response. A signature of open chromatin was associated with genes controlling T cell activation, consistent with the known impact on differentiation. In addition, memory CD8 T cells lacking Zbtb20 were characterized by open chromatin regions with overrepresentatio

SUBMITTER: Preiss NK 

PROVIDER: S-EPMC10326419 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature