Adult intracranial ependymoma-relevance of DNA methylation profiling for diagnosis, prognosis, and treatment.

ABSTRACT:

Background

A methylation-based classification of ependymoma has recently found broad application. However, the diagnostic advantage and implications for treatment decisions remain unclear. Here, we retrospectively evaluate the impact of surgery and radiotherapy on outcome after molecular reclassification of adult intracranial ependymomas.

Methods

Tumors diagnosed as intracranial ependymomas from 170 adult patients collected from 8 diagnostic institutions were subjected to DNA methylation profiling. Molecular classes, patient characteristics, and treatment were correlated with progression-free survival (PFS).

Results

The classifier indicated an ependymal tumor in 73.5%, a different tumor entity in 10.6%, and non-classifiable tumors in 15.9% of cases, respectively. The

SUBMITTER: Trager M 

PROVIDER: S-EPMC10326475 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature