CenTauR: Toward a universal scale and masks for standardizing tau imaging studies.

ABSTRACT:

Introduction

Recently, an increasing number of tau tracers have become available. There is a need to standardize quantitative tau measures across tracers, supporting a universal scale. We developed several cortical tau masks and applied them to generate a tau imaging universal scale.

Method

One thousand forty-five participants underwent tau scans with either ¹⁸F-flortaucipir, ¹⁸F-MK6240, ¹⁸F-PI2620, ¹⁸F-PM-PBB3, ¹⁸F-GTP1, or ¹⁸F-RO948. The universal mask was generated from cognitively unimpaired amyloid beta (Aβ)- subjects and Alzheimer's disease (AD) patients with Aβ+. Four additional regional cortical masks were defined within the constraints of the universal mask. A universal scale, the CenTauR_z,

SUBMITTER: Villemagne VL 

PROVIDER: S-EPMC10326476 | biostudies-literature | 2023 Jul-Sep

REPOSITORIES: biostudies-literature