The effects of low-dose radiation therapy in patients with mild-to-moderate Alzheimer's dementia: an interim analysis of a pilot study.

ABSTRACT:

Purpose

We aimed to determine whether low-dose radiotherapy (LDRT) is effective in patients with Alzheimer disease (AD).

Materials and methods

We included patients according to the following criteria: probable Alzheimer's dementia according to the New Diagnostic Criteria for Alzheimer's Disease; confirmation of amyloid plaque deposits on baseline amyloid positron emission tomography (PET); a Korean Mini-Mental State Examination 2nd edition (K-MMSE-2) score of 13-26; and a Global Clinical Dementia Rating (CDR) score of 0.5-2 points. LDRT was performed six times at 0.5 Gy each. Post-treatment cognitive function tests and PET-CT examinations were performed to evaluate efficacy. The medication for AD treatment was maintained throughout the study period.

Results

At 6 month

SUBMITTER: Kim A 

PROVIDER: S-EPMC10326509 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature