Treatment-associated mRNA co-expression changes in monocytes of patients with posttraumatic stress disorder.

ABSTRACT: PTSD is a prevalent mental disorder that results from exposure to extreme and stressful life events and comes at high costs for both the individual and society. Therapeutic treatment presents the best way to deal with PTSD-the mechanisms underlying change after treatment, however, remain poorly understood. While stress and immune associated gene expression changes have been associated with PTSD development, studies investigating treatment effects at the molecular level so far tended to focus on DNA methylation. Here we use gene-network analysis on whole-transcriptome RNA-Seq data isolated from CD14⁺ monocytes of female PTSD patients (N = 51) to study pre-treatment signatures of therapy response and therapy-related changes at the level of gene expression. Patients who exhi

SUBMITTER: Kumsta R 

PROVIDER: S-EPMC10326517 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature