Functional annotation of uncharacterized proteins from Fusobacterium nucleatum: identification of virulence factors.

ABSTRACT: Fusobacterium nucleatum is a gram-negative bacteria associated with diverse infections like appendicitis and colorectal cancer. It mainly attacks the epithelial cells in the oral cavity and throat of the infected individual. It has a single circular genome of 2.7 Mb. Many proteins in F. nucleatum genome are listed as "Uncharacterized." Annotation of these proteins is crucial for obtaining new facts about the pathogen and deciphering the gene regulation, functions, and pathways along with discovery of novel target proteins. In the light of new genomic information, an armoury of bioinformatic tools were used for predicting the physicochemical parameters, domain and motif search, pattern search, and localization of the uncharacterized proteins. The programs such as receiver operating characte

SUBMITTER: Rauthan K 

PROVIDER: S-EPMC10326533 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature