Ontology highlight
ABSTRACT:
SUBMITTER: Gao R
PROVIDER: S-EPMC10326640 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Gao Rui R Acreman Samuel S Ma Jinfang J Abdulkader Fernando F Wendt Anna A Zhang Quan Q
The Journal of endocrinology 20230626 2
Glucagon is the principal glucose-elevating hormone that forms the first-line defence against hypoglycaemia. Along with insulin, glucagon also plays a key role in maintaining systemic glucose homeostasis. The cells that secrete glucagon, pancreatic α-cells, are electrically excitable cells and use electrical activity to couple its hormone secretion to changes in ambient glucose levels. Exactly how glucose regulates α-cells has been a topic of debate for decades but it is clear that electrical si ...[more]