A greater ratio of thigh subcutaneous fat to abdominal fat is associated with protection against non-alcoholic fatty liver disease.

ABSTRACT:

Background & aims

No prospective studies have examined the association between thigh subcutaneous fat distribution and non-alcoholic fatty liver disease (NAFLD). We investigated the associations of thigh subcutaneous fat distribution with incidence and remission of NAFLD in a community-based prospective cohort.

Methods

We followed 1,787 subjects, who underwent abdominal ultrasonography, abdominal and femoral magnetic resonance imaging scans, and anthropometric assessments. Associations of thigh subcutaneous fat area/abdominal fat area ratio and thigh circumference/waist circumference ratio with incidence and remission of NAFLD were estimated using the modified Poisson regression model.

Results

Over a mean 3.6-year follow-up, 239 incident cases of NAFLD and 207 regress

SUBMITTER: Liang Y 

PROVIDER: S-EPMC10326700 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature