GIP receptor agonism blocks chemotherapy-induced nausea and vomiting.

ABSTRACT:

Objective

Nausea and vomiting remain life-threatening obstacles to successful treatment of chronic diseases, despite a cadre of available antiemetic medications. Our inability to effectively control chemotherapy-induced nausea and vomiting (CINV) highlights the need to anatomically, molecularly, and functionally characterize novel neural substrates that block CINV.

Methods

Behavioral pharmacology assays of nausea and emesis in 3 different mammalian species were combined with histological and unbiased transcriptomic analyses to investigate the beneficial effects of glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism on CINV.

Results

Single-nuclei transcriptomics and histological approaches in rats revealed a topographical, molecularly distinct, GABA-er

SUBMITTER: Borner T 

PROVIDER: S-EPMC10326744 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature