Personal and clinical characteristics associated with immunotherapy effectiveness in stage IV non-small cell lung cancer.

ABSTRACT:

Background

Immunotherapy response rates in metastatic non-small cell lung cancer (NSCLC) are low and survival varies significantly. Factors like age, sex, race, and histology may modulate immunotherapy response. Existing analyses are limited to clinical trials, with limited generalizability, and meta-analyses where adjustment for potential confounders cannot be performed. Here, we conduct a cohort study with patient-level analysis to explore how personal and clinical characteristics moderate chemoimmunotherapy effectiveness in metastatic NSCLC.

Methods

Stage IV NSCLC patients diagnosed in 2015 were drawn from Surveillance Epidemiology, and End Results-Medicare linked data. Receipt of chemoimmunotherapy and overall survival (OS) were the primary predictor and outcome of inter

SUBMITTER: Patel KH 

PROVIDER: S-EPMC10326785 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature