A comparison of the microbiome composition in lower respiratory tract at different sites in early lung cancer patients.

ABSTRACT:

Background

Lung microbiome dysbiosis has been associated with lung carcinogenesis. However, the differences in the microbiome composition at different lung sites of lung cancer patients remain little understood. Studying the whole lung microbiome in cancer patients could provide new insights for interpreting the complex interplay between the microbiome and lung cancer and finding new targets for more effective therapies and preventive measures.

Methods

A total of 16 patients with non-small cell lung cancer (NSCLC) were recruited for this study. Samples were obtained from four sites, including lung tumor tissues (TT), para-tumor tissues (PT), distal normal lung tissues (DN), and bronchial tissues (BT). The DNA was isolated from the tissues, and the V3-V4 regions were amplifie

SUBMITTER: Su K 

PROVIDER: S-EPMC10326795 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature