Clinical Radiosynthesis and Translation of [¹⁸F]OP-801: A Novel Radiotracer for Imaging Reactive Microglia and Macrophages.

ABSTRACT: Positron emission tomography (PET) is a powerful tool for studying neuroinflammatory diseases; however, current PET biomarkers of neuroinflammation possess significant limitations. We recently reported a promising dendrimer PET tracer ([¹⁸F]OP-801), which is selectively taken up by reactive microglia and macrophages. Here, we describe further important characterization of [¹⁸F]OP-801 in addition to optimization and validation of a two-step clinical radiosynthesis. [¹⁸F]OP-801 was found to be stable in human plasma for 90 min post incubation, and human dose estimates were calculated for 24 organs of interest; kidneys and urinary bladder wall without bladder voiding were identified as receiving the highest absorbed dose. Following optimization detailed herein

SUBMITTER: Jackson IM 

PROVIDER: S-EPMC10326869 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature