Cardiac contractility is a key factor in determining pulse pressure and its peripheral amplification.

ABSTRACT:

Background

Arterial stiffening and peripheral wave reflections have been considered the major determinants of raised pulse pressure (PP) and isolated systolic hypertension, but the importance of cardiac contractility and ventricular ejection dynamics is also recognised.

Methods

We examined the contributions of arterial compliance and ventricular contractility to variations in aortic flow and increased central (cPP) and peripheral (pPP) pulse pressure, and PP amplification (PPa) in normotensive subjects during pharmacological modulation of physiology, in hypertensive subjects, and in silico using a cardiovascular model accounting for ventricular-aortic coupling. Reflections at the aortic root and from downstream vessels were quantified using emission and reflection coe

SUBMITTER: Piccioli F 

PROVIDER: S-EPMC10326904 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature