Monitoring SARS-CoV-2 variants in wastewater of Dhaka City, Bangladesh: approach to complement public health surveillance systems.

ABSTRACT:

Background

Wastewater-based epidemiological surveillance has been considered a powerful tool for early detection and monitoring of the dynamics of SARS-CoV-2 and its lineages circulating in a community. This study is aimed to investigate the complexity of SARS-CoV-2 infection dynamics in Dhaka city by examining its genetic variants in wastewater. Also, the study seeks to determine a connection between the SARS-CoV-2 variations detected in clinical testing and those found in wastewater samples.

Results

Out of 504 samples tested in RT-qPCR, 185 (36.7%) tested positive for SARS-CoV-2 viral RNA. The median log₁₀ concentration of SARS-CoV-2 N gene copies/Liter of wastewater (gc/L) was 5.2, and the median log₁₀ concentration of ORF1ab was 4.9. To further reve

SUBMITTER: Haque R 

PROVIDER: S-EPMC10326934 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature