Altered levels of transthyretin in human cerebral microdialysate after subarachnoid haemorrhage using proteomics; a descriptive pilot study.

ABSTRACT:

Background

Subarachnoid haemorrhage (SAH) is one of the most severe forms of stroke in which delayed cerebral ischemia is one of the major complications. Neurointensive care aims at preventing and treating such complications and identification of biomarkers of early signs of ischemia might therefore be helpful.

Methods

We aimed at describing proteome profile in cerebral microdialysate in four patients with aneurysmal SAH using two dimensional gel electrophoresis in combination with mass spectrometry in search for new biomarkers for delayed cerebral ischemia and to investigate if there were temporal fluctuations in those biomarkers over time after aneurysmal bleed.

Results

The results showed transthyretin in nine different proteoforms (1001, 1102, 2101, 3101, 4101, 410

SUBMITTER: Ginstman F 

PROVIDER: S-EPMC10326944 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature