The origin and structural evolution of de novo genes in Drosophila.

ABSTRACT: Although previously thought to be unlikely, recent studies have shown that de novo gene origination from previously non-genic sequences is a relatively common mechanism for gene innovation in many species and taxa. These young genes provide a unique set of candidates to study the structural and functional origination of proteins. However, our understanding of their protein structures and how these structures originate and evolve are still limited, due to a lack of systematic studies. Here, we combined high-quality base-level whole genome alignments, bioinformatic analysis, and computational structure modeling to study the origination, evolution, and protein structure of lineage-specific de novo genes. We identified 555 de novo gene candidates in D. melanogaster

SUBMITTER: Peng J 

PROVIDER: S-EPMC10326970 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature