Hippocampal contributions to novel spatial learning are both age-related and age-invariant.

ABSTRACT: Older adults show declines in spatial memory, although the extent of these alterations is not uniform across the healthy older population. Here, we investigate the stability of neural representations for the same and different spatial environments in a sample of younger and older adults using high-resolution functional magnetic resonance imaging (fMRI) of the medial temporal lobe. Older adults showed, on average, lower neural pattern similarity for retrieving the same environment and more variable neural patterns compared to young adults. We also found a positive association between spatial distance discrimination and the distinctiveness of neural patterns between environments. Our analyses suggested that one source for this association was the extent of informational connectivity to CA1 f

SUBMITTER: Zheng L 

PROVIDER: S-EPMC10326977 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature