Specific prostaglandins are produced in the migratory cells and the surrounding substrate to promote Drosophila border cell migration.

ABSTRACT: A key regulator of collective cell migration is prostaglandin (PG) signaling. However, it remains largely unclear whether PGs act within the migratory cells or their microenvironment to promote migration. Here we use Drosophila border cell migration as a model to uncover the cell-specific roles of two PGs in collective migration. Prior work shows PG signaling is required for on-time migration and cluster cohesion. We find that the PGE₂ synthase cPGES is required in the substrate, while the PGF_2α synthase Akr1B is required in the border cells for on-time migration. Akr1B acts in both the border cells and their substrate to regulate cluster cohesion. One means by which Akr1B regulates border cell migration is by promoting integrin-based adhesions. Additionally, A

SUBMITTER: Mellentine SQ 

PROVIDER: S-EPMC10327004 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature