Whole-brain annotation and multi-connectome cell typing quantifies circuit stereotypy in <i>Drosophila</i>.

ABSTRACT: The fruit fly Drosophila melanogaster combines surprisingly sophisticated behaviour with a highly tractable nervous system. A large part of the fly's success as a model organism in modern neuroscience stems from the concentration of collaboratively generated molecular genetic and digital resources. As presented in our FlyWire companion paper ¹ , this now includes the first full brain connectome of an adult animal. Here we report the systematic and hierarchical annotation of this ~130,000-neuron connectome including neuronal classes, cell types and developmental units (hemilineages). This enables any researcher to navigate this huge dataset and find systems and neurons of interest, linked to the literature through the Virtual Fly Brain database ² . Crucially, th

SUBMITTER: Schlegel P 

PROVIDER: S-EPMC10327018 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature