Single-cell Transcriptomic Analysis of Salivary Gland Endothelial Cells.

ABSTRACT: Vascular endothelial cells have important functions in fibrosis via direct and indirect methods and in regeneration through secretion of tissue-specific, paracrineacting angiocrine factors. In the salivary gland, endothelial cells are required for proper development, but their roles within adult glands are largely unknown. The goal of this work was to identify ligand-receptor interactions between endothelial cells and other cell types that are important during homeostasis, fibrosis, and regeneration. To model salivary gland fibrosis and regeneration, we utilized a reversible ductal ligation. To induce injury, a clip was applied to the primary ducts for 14 days, and to induce a regenerative response, the clip was subsequently removed for 5 days. To identify endothelial cell-produced factors

SUBMITTER: Altrieth AL 

PROVIDER: S-EPMC10327062 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature