Cell Type- and Tissue-specific Enhancers in Craniofacial Development.

ABSTRACT: The genetic basis of craniofacial birth defects and general variation in human facial shape remains poorly understood. Distant-acting transcriptional enhancers are a major category of non-coding genome function and have been shown to control the fine-tuned spatiotemporal expression of genes during critical stages of craniofacial development^1-3. However, a lack of accurate maps of the genomic location and cell type-specific in vivo activities of all craniofacial enhancers prevents their systematic exploration in human genetics studies. Here, we combined histone modification and chromatin accessibility profiling from different stages of human craniofacial development with single-cell analyses of the developing mouse face to create a comprehensive catalogue of the regulatory

SUBMITTER: Rajderkar SS 

PROVIDER: S-EPMC10327103 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature