Wound-Induced Syncytia Outpace Mononucleate Neighbors during Drosophila Wound Repair.

ABSTRACT: All organisms have evolved to respond to injury. Cell behaviors like proliferation, migration, and invasion replace missing cells and close wounds. However, the role of other wound-induced cell behaviors is not understood, including the formation of syncytia (multinucleated cells). Wound-induced epithelial syncytia were first reported around puncture wounds in post-mitotic Drosophila epidermal tissues, but have more recently been reported in mitotically competent tissues such as the Drosophila pupal epidermis and zebrafish epicardium. The presence of wound-induced syncytia in mitotically active tissues suggests that syncytia offer adaptive benefits, but it is unknown what those benefits are. Here, we use in vivo live imaging to analyze wound-induced syncytia in mitotic

SUBMITTER: White JS 

PROVIDER: S-EPMC10327115 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature