Genetic risk assessment of lethal prostate cancer using polygenic risk score and hereditary cancer susceptibility genes.

ABSTRACT:

Background

The genetic risk of aggressive prostate cancer (PCa) is hard to be assessed due to the lack of aggressiveness-related single-nucleotide polymorphisms (SNPs). Prostate volume (PV) is a potential well-established risk factor for aggressive PCa, we hypothesize that polygenic risk score (PRS) based on benign prostate hyperplasia (BPH) or PV-related SNPs may also predict the risk of aggressive PCa or PCa death.

Methods

We evaluated a PRS using 21 BPH/PV-associated SNPs, two established PCa risk-related PRS and 10 guideline-recommended hereditary cancer risk genes in the population-based UK Biobank cohort (N = 209,502).

Results

The BPH/PV PRS was significantly inversely associated with the incidence of lethal PCa as well as the natural progress in PCa patients (h

SUBMITTER: Ruan X 

PROVIDER: S-EPMC10327136 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature