Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints.

ABSTRACT: RAC1^P29S is the third most prevalent hotspot mutation in sun-exposed melanoma. RAC1 alterations in cancer are correlated with poor prognosis, resistance to standard chemotherapy, and insensitivity to targeted inhibitors. Although RAC1^P29S mutations in melanoma and RAC1 alterations in several other cancers are increasingly evident, the RAC1-driven biological mechanisms contributing to tumorigenesis remain unclear. Lack of rigorous signaling analysis has prevented identification of alternative therapeutic targets for RAC1^P29S-harboring melanomas. To investigate the RAC1^P29S-driven effect on downstream molecular signaling pathways, we generated an inducible RAC1^P29S expression melano

SUBMITTER: Cannon AC 

PROVIDER: S-EPMC10327161 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature