HOXDeRNA activates a cancerous transcription program and super-enhancers genome-wide.

ABSTRACT:

Background

The origin and genesis of highly malignant and heterogenous glioblastoma brain tumors remain unknown. We previously identified an enhancer-associated long non-coding RNA, LINC01116 (named HOXDeRNA here), that is absent in the normal brain but is commonly expressed in malignant glioma. HOXDeRNA has a unique capacity to transform human astrocytes into glioma-like cells. This work aimed to investigate molecular events underlying the genome-wide function of this lncRNA in glial cell fate and transformation.

Results

Using a combination of RNA-Seq, ChIRP-Seq, and ChIP-Seq, we now demonstrate that HOXDeRNA binds in trans to the promoters of genes encoding 44 glioma-specific transcription factors distributed throughout the genome and derepresses them by removing th

SUBMITTER: Deforzh E 

PROVIDER: S-EPMC10327164 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature