Integrative metabolomics differentiate coronary artery disease, peripheral artery disease, and venous thromboembolism risks.

ABSTRACT:

Rationale

Arterial and venous cardiovascular conditions, such as coronary artery disease (CAD), peripheral artery disease (PAD), and venous thromboembolism (VTE), are genetically correlated. Interrogating distinct and overlapping mechanisms may shed new light on disease mechanisms.

Objective

In this study, we aimed to: identify and compare (1) epidemiologic and (2) causal, genetic relationships between metabolites and CAD, PAD, and VTE.

Methods

We used metabolomic data from 95,402 individuals in the UK Biobank, excluding individuals with prevalent cardiovascular disease. Logistic regression models adjusted for age, sex, genotyping array, first five principal components of ancestry, and statin use estimated the epidemiologic associations of 249 metabolites with inciden

SUBMITTER: Lee J 

PROVIDER: S-EPMC10327201 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature