Genetics and Environment Distinctively Shape the Human Immune Cell Epigenome.

ABSTRACT: The epigenomic landscape of human immune cells is dynamically shaped by both genetic factors and environmental exposures. However, the relative contributions of these elements are still not fully understood. In this study, we employed single-nucleus methylation sequencing and ATAC-seq to systematically explore how pathogen and chemical exposures, along with genetic variation, influence the immune cell epigenome. We identified distinct exposure-associated differentially methylated regions (eDMRs) corresponding to each exposure, revealing how environmental factors remodel the methylome, alter immune cell states, and affect transcription factor binding. Furthermore, we observed a significant correlation between changes in DNA methylation and chromatin accessibility, underscoring the coordinat

SUBMITTER: Wang W 

PROVIDER: S-EPMC10327221 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature