Genetic meta-analysis of levodopa induced dyskinesia in Parkinson's disease.

ABSTRACT:

Importance

Forty percent of Parkinson's disease patients develop levodopa-induced-dyskinesia (LiD) within 4 years of starting levodopa. The genetic basis of LiD remains poorly understood, and there have been few well powered studies.

Objective

To discover common genetic variants in the PD population that increase the probability of developing LiD.

Design setting and participants

We performed survival analyses to study the development of LiD in 5 separate longitudinal cohorts. We performed a meta-analysis to combine the results of genetic association from each study based on a fixed effects model weighting the effect sizes by the inverse of their standard error. The selection criteria was specific to each cohort. We studied individuals that were genotyped from each coh

SUBMITTER: Martinez-Carrasco A 

PROVIDER: S-EPMC10327264 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature