An integrative multi-omics analysis based on disulfidptosis-related prognostic signature and distinct subtypes of clear cell renal cell carcinoma.

ABSTRACT:

Background

The association between clear cell renal cell carcinoma (ccRCC) and disulfidoptosis remains to be thoroughly investigated.

Methods

We conducted multiple bioinformatics analyses, including prognostic analysis and cluster analysis, using R software. Additionally, we utilized Quantitative Real-time PCR to measure RNA levels of specific genes. The proliferation of ccRCC was assessed through CCK8 and colony formation assays, while the invasion and migration of ccRCC cells were evaluated using the transwell assay.

Results

In this study, utilizing data from multiple ccRCC cohorts, we identified molecules that contribute to disulfidoptosis. We conducted a comprehensive investigation into the prognostic and immunological roles of these molecules. Among the disulfido

SUBMITTER: Zhang D 

PROVIDER: S-EPMC10327293 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature