Plasma protein biomarkers reflective of the host response in patients developing Intensive Care Unit-acquired pneumonia.

ABSTRACT:

Background

Immune suppression has been implicated in the occurrence of pneumonia in critically ill patients. We tested the hypothesis that Intensive Care Unit (ICU)-acquired pneumonia is associated with broad host immune aberrations in the trajectory to pneumonia, encompassing inflammatory, endothelial and coagulation responses. We compared plasma protein biomarkers reflecting the systemic host response in critically ill patients who acquire a new pneumonia (cases) with those who do not (controls).

Methods

We performed a nested case-control study in patients undergoing mechanical ventilation at ICU admission with an expected stay of at least 48 h enrolled in 30 hospitals in 11 European countries. Nineteen host response biomarkers reflective of key pathophysiological domains

SUBMITTER: van Engelen TSR 

PROVIDER: S-EPMC10327365 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature