Targeting lymph node delivery with nanovaccines for cancer immunotherapy: recent advances and future directions.

ABSTRACT: Although cancer immunotherapy is a compelling approach against cancer, its effectiveness is hindered by the challenge of generating a robust and durable immune response against metastatic cancer cells. Nanovaccines, specifically engineered to transport cancer antigens and immune-stimulating agents to the lymph nodes, hold promise in overcoming these limitations and eliciting a potent and sustained immune response against metastatic cancer cells. This manuscript provides an in-depth exploration of the lymphatic system's background, emphasizing its role in immune surveillance and tumor metastasis. Furthermore, it delves into the design principles of nanovaccines and their unique capability to target lymph node metastasis. The primary objective of this review is to provide a comprehensive ove

SUBMITTER: Li Y 

PROVIDER: S-EPMC10327386 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature