Peelable Microneedle Patches Deliver Fibroblast Growth Factors to Repair Skin Photoaging Damage.

ABSTRACT: Rationale: UV light deeply penetrates the dermis, leading to inflammation and cell death with prolonged exposure. This is a major contributor to skin photoaging. In the pharmaceutical field, fibroblast growth factors (FGFs) have gained popularity for enhancing skin quality as they facilitate tissue remodeling and re-epithelization. Nonetheless, their effectiveness is significantly hindered by limited absorption. Methods: We have successfully created a dissolving microneedle (MN) patch that contains hyaluronic acid (HA) loaded with FGF-2 and FGF-21. This patch aims to improve the therapeutic efficiency of these growth factors while providing a simple administration method. We determined the performance of this patch in an animal model of skin photoaging. Results: The FG

SUBMITTER: Yang G 

PROVIDER: S-EPMC10327422 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature