Enteric fever cluster identification in South Africa using genomic surveillance of Salmonella enterica serovar Typhi.

ABSTRACT: The National Institute for Communicable Diseases in South Africa participates in national laboratory-based surveillance for human isolates of Salmonella species. Laboratory analysis includes whole-genome sequencing (WGS) of isolates. We report on WGS-based surveillance of Salmonella enterica serovar Typhi (Salmonella Typhi) in South Africa from 2020 through 2021. We describe how WGS analysis identified clusters of enteric fever in the Western Cape Province of South Africa and describe the epidemiological investigations associated with these clusters. A total of 206 Salmonella Typhi isolates were received for analysis. Genomic DNA was isolated from bacteria and WGS was performed using Illumina NextSeq technology. WGS data were investigated using multiple bioinfor

SUBMITTER: Smith AM 

PROVIDER: S-EPMC10327498 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature