A novel variant of the Listeria monocytogenes type VII secretion system EssC component is associated with an Rhs toxin.

ABSTRACT: The type VIIb protein secretion system (T7SSb) is found in Bacillota (firmicute) bacteria and has been shown to mediate interbacterial competition. EssC is a membrane-bound ATPase that is a critical component of the T7SSb and plays a key role in substrate recognition. Prior analysis of available genome sequences of the foodborne bacterial pathogen Listeria monocytogenes has shown that although the T7SSb was encoded as part of the core genome, EssC could be found as one of seven different sequence variants. While each sequence variant was associated with a specific suite of candidate substrate proteins encoded immediately downstream of essC, many LXG-domain proteins were encoded across multiple essC sequence variants. Here, we have extended this analysis using a

SUBMITTER: Bowran K 

PROVIDER: S-EPMC10327511 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature