Pan-cancer analysis of the prognostic and immunological role of GJB2: a potential target for survival and immunotherapy.

ABSTRACT:

Background

GJB2 plays an essential role in the growth and progression of several cancers. However, asystematic pan-cancer analysis of GJB2 is lacking. Therefore, in this study, we performed a comprehensive pan-cancer analysis to determine the potential role of GJB2 in prognostic prediction and cancer immunotherapy response.

Methods

The differential expression of GJB2 in the tumor and adjacent normal tissues of various cancer types was analyzed using the TIMER, GEPIA, and Sangerbox databases. GEPIA and Kaplan-Meier plotter databases were used to analyze the survival outcomes based on GJB2 expression levels in pan-cancer. Furthermore, the association of GJB2 expression with the immune checkpoint (ICP) genes, tumor mutational load (TMB), microsatellite instability (MSI), neoant

SUBMITTER: Jia Y 

PROVIDER: S-EPMC10327570 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature