Application of next generation sequencing in cardiology: current and future precision medicine implications.

ABSTRACT: Inherited cardiovascular diseases are highly heterogeneous conditions with multiple genetic loci involved. The application of advanced molecular tools, such as Next Generation Sequencing, has facilitated the genetic analysis of these disorders. Accurate analysis and variant identification are required to maximize the quality of the sequencing data. Therefore, the application of NGS for clinical purposes should be limited to laboratories with a high level of technological expertise and resources. In addition, appropriate gene selection and variant interpretation can result in the highest possible diagnostic yield. Implementation of genetics in cardiology is imperative for the accurate diagnosis, prognosis and management of several inherited disorders and could eventually lead to the realiza

SUBMITTER: Papadopoulou E 

PROVIDER: S-EPMC10327645 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature