Impact of TREM1 Variants on the Risk and Prognosis of Glioma in the Chinese Han Population.

ABSTRACT:

Background

Glioma is the main pathological subtype of brain tumors with high mortality.

Objective

This study aimed to elucidate the correlation between TREM1 variants and glioma risk in the Chinese Han population.

Methods

Genotyping of six variants of TREM1 was completed by Agena MassARRAY platform in 1061 subjects (503 controls and 558 glioma patients). The relationship between TREM1 polymorphisms and glioma risk was calculated using the logistic regression model, with odds ratio (OR) and 95% confidence intervals (CIs). A multifactor dimensionality reduction (MDR) method was performed to assess SNP-SNP interactions to predict glioma risk.

Results

In this research, overall analysis illustrated an association between TREM1 rs9369269 a

SUBMITTER: Hu M 

PROVIDER: S-EPMC10327902 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature