Intracellular Loop in the Brain Isoforms of Anoctamin 2 Channels Regulates Calcium-dependent Activation.

ABSTRACT: Anoctamin 2 (ANO2 or TMEM16B), a calcium-activated chloride channel (CaCC), performs diverse roles in neurons throughout the central nervous system. In hippocampal neurons, ANO2 narrows action potential width and reduces postsynaptic depolarization with high sensitivity to Ca²⁺ at relatively fast kinetics. In other brain regions, including the thalamus, ANO2 mediates activity-dependent spike frequency adaptations with low sensitivity to Ca²⁺ at relatively slow kinetics. How this same channel can respond to a wide range of Ca²⁺ levels remains unclear. We hypothesized that splice variants of ANO2 may contribute to its distinct Ca²⁺ sensitivity, and thus its diverse neuronal functions. We identified two ANO2 isoforms expressed in mouse brains and ex

SUBMITTER: Lee D 

PROVIDER: S-EPMC10327929 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature